Mechanisms of cytokine-mediated localized immunoprotection.

Mechanisms of cytokine-mediated localized immunoprotection

T he actions ofproinflammatory or regulatory cytokines have been quite unpredictable when expressed individually within tissues such as in transgenic mice. Cytokines that have been considered proinflammatory in the classical sense have been shown to have immunosuppressive effects; likewise, cytokines that have demonstrated immunosuppressive activity have proven to be proinflammatory in these tr...

Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis

Anemia of cancer and chronic inflammatory diseases is a frequent complication affecting quality of life. For cancer patients it represents a particularly bad prognostic. Low level of erythropoietin is considered as one of the causes of anemia in these pathologies. The deficiency in erythropoietin production results from pro-inflammatory cytokines effect. However, few data is available concernin...

Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis.

This study examined the role of nitric oxide (NO) in cytokine-induced apoptosis in adult cardiac fibroblasts (CFbs). In cultured adult rat CFbs, IL-1beta (5 ng/ml), but not interferon-gamma (10 ng/ml) or tumor necrosis factor-alpha (10 ng/ml), induced inducible NO synthase (iNOS) expression and NO production that was associated with an increase in caspase-3 activity and apoptotic cell death. Ap...

Mechanisms of Soluble Cytokine Receptor

Mechanisms of eosinophil cytokine release.

Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associat...